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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Hum Genet. 2019 Nov 4;138(11-12):1301–1311. doi: 10.1007/s00439-019-02073-x

Fig. 3.

Fig. 3.

Analyses of FOXF1 expression. (A) FOXF1 transcript levels in the lungs from the patients with the heterozygous 16q23.3q24.1 CNV deletions. (B) Luciferase reporter assay showing the increase of FOXF1 promoter activity by SNV rs150502618-A. (C-D) Regulation of FOXF1 expression by TFAP2s in IMR-90 lung fibroblasts. Depletion of TFAP2C by siRNA resulted in a significant decrease of FOXF1 transcript levels. Data represent means of triplicate experiments ± SD (t test *P ≤ 0.01). Abbreviations: Cn, normal lung controls used as calibrator; C2yo, normal lung of 2 year-old child for comparison with pt 165.3.