TABLE 1.
Global/regional CBF and oxygen delivery. Measurements presented as global (GM/WM) with mean ± SD, values in bold indicates significant difference with P < 0.01
| Regions | CTL (N = 25) | SCD (N = 32) |
P-value (adjusted) |
|
|---|---|---|---|---|
| CBF (mL/100 g/min) | ||||
| Whole brain | Total | 54.7 ± 12.9 | 72.2 ± 21.0 | 0.0006 |
| GM | 63.0 ± 14.7 | 84.0 ± 26.5 | 0.0006 | |
| WM | 41.2 ± 11.6 | 37.62 ± 9.6 | 0.2 | |
| ACA | Total | 46.5 ± 9.7 | 74.7 ± 27.3 | <0.0001 |
| GM | 53.4 ± 11.5 | 87.0 ± 33.8 | <0.0001 | |
| WM | 34.9 ± 8.4 | 38.8 ± 12.4 | 0.2 | |
| MCA | Total | 58.4 ± 14.0 | 79.1 ± 23.5 | 0.0003 |
| GM | 67.0 ± 16.7 | 92.1 ± 29.6 | 0.0004 | |
| WM | 44.0 ± 12.1 | 41.3 ± 11.0 | 0.4 | |
| PCA | Total | 56.4 ± 12.5 | 74.3 ± 22.9 | 0.0009 |
| GM | 64.7 ± 12.9 | 86.5 ± 28.9 | 0.001 | |
| WM | 42.5 ± 14.7 | 38.6 ± 9.7 | 0.2 | |
| Oxygen delivery (mL Oxygen/100 g/min) | ||||
| Whole brain | Total | 11.3 ± 3.0 | 10.4 ± 2.2 | 0.2 |
| GM | 12.9 ± 3.5 | 12.0 ± 2.8 | 0.3 | |
| WM | 8.5 ± 2.7 | 5.5 ± 1.3 | <0.0001 | |
| ACA | Total | 9.6 ± 2.2 | 10.6 ± 2.9 | 0.1 |
| GM | 11.0 ± 2.6 | 12.3 ± 3.6 | 0.1 | |
| WM | 7.2 ± 2.0 | 5.6 ± 1.5 | 0.001 | |
| MCA | Total | 12.1 ± 3.4 | 11.2 ± 2.4 | 0.3 |
| GM | 13.8 ± 4.0 | 13.1 ± 3.1 | 0.4 | |
| WM | 9.1 ± 2.9 | 5.9 ± 1.4 | <0.0001 | |
| PCA | Total | 11.6 ± 2.9 | 10.6 ± 2.3 | 0.1 |
| GM | 13.4 ± 3.5 | 12.3 ± 3.0 | 0.2 | |
| WM | 8.8 ± 2.7 | 5.5 ± 1.2 | <0.0001 | |
Abbreviations: CTL, controls; SCD, sickle cell disease; CBF, cerebral blood flow; ACA, anterior cerebral artery; MCA, middle cerebral artery; PCA, posterior cerebral artery.