TABLE 2.

Univariate predictors of SCD brain perfusion and oxygen delivery

Brain perfusion sickle cell disease patients
Predictor	Total perfusion	GM perfusion	WM perfusion
Plasma hemoglobin	r2 = 0.38, P = 0.0002	r2 = 0.38, P = 0.0002	-
Lactate dehydrogenase	r2 = 0.58, P < 0.0001	r2 = 0.54, P = <0.0001	r2 = 0.23, P = 0.006
Reticulocyte count	r2 = 0.27, P = 0.002	r2 = 0.27, P = 0.002	-
Mean platelet volume	r2 = 0.23, P = 0.005	r2 = 0.22, P = 0.007	-
Heart rate	r2 = 0.29, P = 0.002	r2 = 0.24, P = 0.004	r2 = 0.19, P = 0.01
Weight	-	-	r2 = 0.16, P = 0.02
Age	-	-	r2 = 0.20, P = 0.01
MCHC	r2 = 0.12, P = 0.05	r2 = 0.12, P = 0.05	-
Oxygen content	r2 = 0.37 P = 0.0002	r2 = 0.34 P = 0.0004	r2 = 0.14, P = 0.03
Hemoglobin	r2 = 0.36, P = 0.0003	r2 = 0.33, P = 0.0006	r2 = 0.17, P = 0.03
Hematocrit	r2 = 0.37, P = 0.0002	r2 = 0.33, P = 0.0006	r2 = 0.22, P = 0.007
RDW	r2 = 0.09, P = 0.09	r2 = 0.10, P = 0.07	r2 = 0.14, P = 0.03
White blood cell count	r2 = 0.12, P = 0.05	r2 = 0.11, P = 0.06	-
Oxygen delivery in sickle cell disease patients
Predictor	Total O2 delivery	GM O2 delivery	WM O2 delivery
Plasma hemoglobin	r2 = 0.30, P = 0.001	r2 = 0.33, P = 0.0007	-
Lactate dehydrogenase	r2 = 0.10, P = 0.07	r2 = 0.11, P = 0.07	-
Mean platelet volume	r2 = 0.17, P = 0.02	r2 = 0.17, P = 0.02	-
Hemoglobin S%	r2 = 0.10, P = 0.07	r2 = 0.11, P = 0.06	-
Age	-	-	r2 = 0.24, P = 0.005
MCHC	-	-	r2 = 0.22, P = 0.007
Oxygen content	-	-	r2 = 0.18, P = 0.02
Hemoglobin	-	-	r2 = 0.15, P = 0.03
Hematocrit	-	-	r2 = 0.09, P = 0.09
RDW	-	-	r2 = 0.14, P = 0.03
Reticulocyte count	-	-	r2 = 0.14, P = 0.04

Abbreviations: MCHC, mean corpuscular hemoglobin concentration; RDW: red cell distribution width; GM: gray matter; WM: white matter; O₂: oxygen.Bold letter indicates retention on multivariate analysis.