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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Hum Mutat. 2019 Sep 15;40(12):2171–2183. doi: 10.1002/humu.23819

FIGURE 5. Pathogenic human single nucleotide polymorphisms (SNPs) in the ClinVar database.

FIGURE 5

According to the ClinVar database, there are about 48% pathogenic human SNPs caused by G•C to A•T conversion, and 14% SNPs caused by T•A to C•G conversion. These two types of pathogenic human SNPs can be corrected by adenine base editors (ABEs) and cytosine base editors (CBEs).