Table 2:

List of major base editors with their approximate editing windows and efficiency

Base editor	Construction (N to C)	PAM	Editing window	Efficiency	References
SaBE3	rAPOCBEC1-SaCas9n-UGI	NNGRRT (R=G or A)	N9 to N15	~50%	Y. B. Kim et al., 2017
CBE4	rAPOCBEC1-Cas9n-UGI-UGI	NGG	N13 to N17	~50%	Komor et al., 2017
SaBE4-Gam	Gam-rAPOCBEC1-SaCas9n-UGI-UGI	NNGRRT	N9 to N15	~50%	Komor et al., 2017
HF2-BE2	APOCBEC1-HF2-dCas9-UGI	NGG	N/A	100%	Liang, Sun, et al., 2017
BE-PLUS	nCas9-GCN4, scFv-APOBEC-UGI	NGG	N5 to N17	42.2%	Jiang et al., 2018
dCpf1-BEs	+/−NLS, rAPOCBEC1-YE-dCpf1-UGI, +/−3xFree UGI	TTTV	N8 to N13	~10–31%	Li et al., 2018
TAM	dcas9-AID (AIDx), +/−UGI	NGG	N12 to N16	52%	Ma et al., 2016
CRISPR-X	dCas9-directed MS2–AID*Δ	NGG	N50 to -N50	> 20%	Hess et al., 2016
Target-AID	dCas9-PmCDA1-UGI/Cas9n-PmCDA1-UGI	NG	N15 to N19	15%−55%	Nishida et al., 2016
TALE-AID ZFN-AID	TALE-AID ZFN-AID	N/A	N/A	2.5%	Luhan Yang et al., 2016
ABE7.10	TadA-TadA(7.10)*–XTEN–Cas9n–NLS	NGG	N13 to N17	58%±4.0%	Gaudelli et al., 2017
xABE	TadA-TadA(7.10)*–XTEN–xCas9–NLS	NG, GAA, and GAT	N13 to N17	N/A	Hu et al., 2018
SaABE	TadA-TadA(7.10)*–XTEN–SaCas9n–NLS	NNGRRT	N9 to N15	N/A	Hua, Tao, & Zhu, 2019
VQR-ABE	TadA-TadA(7.10)*–XTEN–VQR-Cas9n–NLS	NGA	N13 to N17	N/A	Hua, Tao, & Zhu, 2019 L. Yang et al., 2018
VRER-ABE	TadA-TadA(7.10)*–XTEN–VRER-Cas9n–NLS	NGCG	N13 to N17	N/A	Hua, Tao, & Zhu, 2019
Sa(KKH)- ABE	TadA-TadA(7.10)*–XTEN–Sa(KKH)- ABE -Cas9n–NLS	NNNRRT	N9 to N15	N/A	Hua, Tao, & Zhu, 2019 L. Yang et al., 2018