Table 2: Repeat dosing of 40 kDa free PEG does not affect clinical blood chemistry or urinalysis results.
PEG 40 kDa (in vaccinated mice)
Sensitized mice were given six weekly injections of 40 kDa free PEG (550 mg/kg) or PBS, and urine and terminal blood were collected. Terminal blood was collected via cardiac puncture. Complete blood counts were performed within 60 minutes of sample collection, and serum/urine tests were performed according to manufacturer recommendations.
| vax + PBS (n=5) | vax + PEG (n=9) | p-value | ||
|---|---|---|---|---|
| Complete Blood Count | ||||
| Red blood cell(M/μL) | 10.3 | 10.2 | 0.7 | |
| Hemoglobin (g/dL) | 16.3 | 15.6 | 0.17 | |
| Hematocrit (%) | 49.7 | 47.6 | 0.14 | |
| MCV (fL) | 48.1 | 46.5 | 0.01 | |
| Platelet (K/μL) | 77 | 131.22 | 0.46 | |
| Reticulocyte (K/μL) | 446.16 | 523.97 | 0.43 | |
| WBC (K/μL) | 4.82 | 4.62 | 0.76 | |
| Neutrophil # (K/μL) | 0.9 | 1.03 | 0.70 | |
| Lymphocyte # (K/μL) | 3.4 | 3.38 | 0.97 | |
| Serum | ||||
| Creatinine (mq/dL) | 0.1 | 0.1 | 0.86 | |
| Total protein (g/dL) | 4.9 | 5.0 | 0.22 | |
| BUN (mg/dL) | 19.2 | 20.8 | 0.03 | |
| ALT (U/L) | 31.8 | 32.3 | 0.98 | |
| AST (U/L) | 179.8 | 103.1 | 0.07 | |
| Urine (n=8PEG, 5 PBS) | ||||
| Creatinine (mg/dL) | 70.7 | 54.1 | 0.157 | |
| Total protein (mg/dL) | 200.6 | 93.6 | 0.090 |