Table 3.
Complete blood count and blood chemistry analyses upon IV injections a.
| Treated Mice Dose |
Control | Stöber 100 | Meso 100 | Disulfide Hollow 100 |
|---|---|---|---|---|
| 0.9% Normal Saline |
25 mg kg−1 | 25 mg kg−1 | 25 mg kg−1 | |
| ❖ Complete Blood Count | ||||
| ✓ White Blood Cell (103/μL) | 1.35 ± 0.30** | 2.12 ± 1.52** | 2.07 ± 0.88** | 1.63 ± 0.56 |
| ▪ Neutrophil (103/μL) | 0.28 ± 0.07 | 0.31 ± 0.11 | 0.37 ± 0.16 | 0.28 ± 0.08 |
| ▪ Basophil (103/μL) | 0.02** | 0.02 ± 0.01 | 0.04 ± 0.06 | 0.007 ± 0.004** |
| ▪ Eosinophil (103/μL) | 0.06 ± 0.02** | 0.11 ± 0.08** | 0.22 ± 0.09** | 0.05 ± 0.01 |
| ▪ Monocyte (103/μL) | 0.02 ± 0.01** | 0.07 ± 0.04 | 0.13 ± 0.03** | 0.07 ± 0.01 |
| ▪ Lymphocyte (103/μL) | 0.96 ± 0.50 | 1.59 ± 0.47** | 1.29 ± 0.33 | 1.22 ± 0.49 |
| ✓ Reb Blood Cell (106/μL) | 8.39 ± 0.21 | 7.67 ± 2.39 | 7.98 ± 0.27 | 8.77 ± 0.50 |
| ✓ Hemoglobin (g/dL) | 14.82 ± 0.10 | 13.43 ± 4.24 | 14.66 ± 0.37 | 15.02 ± 0.64 |
| ✓ Platelet (103/μL) | 895 ± 128** | 295.44 ± 28.56** | 262.87 ± 48.32** | 843.14 ± 76.18 |
| ❖ Blood Chemistry | ||||
| ✓ Blood Urea Nitrogen (mg/dL) | 18.93 ± 3.30 | 21.45 ± 3.46 | 21 ± 0.70 | 19.3 ± 4.55 |
| ✓ Total Protein (g/dL) | 5.33 ± 0.32 | 4.75 ± 0.21 | 5.23 ± 0.20 | 5.3 ± 0.36 |
| ✓ Glucose (mg/dL) | 225.66 ± 24.68 | 312.5 ± 60.10 | 258 ± 29.05 | 233 ± 61.73 |
| ✓ ALT (GPT; IU/L) | 24.33 ± 5.50** | 55.5 ± 13.06** | 23.66 ± 9.29** | 21 ± 3.60 |
| ✓ AST (GOT; IU/L) | 101 ± 36.76 | 123.5 ± 14.84 | 94 ± 5.65 | 67.33 ± 8.14 |
| ✓ ALP (IU/L) | 62 ± 1 | 71 | 76.33 ± 16.07 | 71.66 ± 11.50 |
a
Data are mean ± SD (N=3).
**
means statistically significant difference (Pvalue< 0.05) was observed between nanoparticle-injected mice and the control group. ANOVA followed by a Dunnett’s post-hoc test was applied for statistical analyses.