Table 1.

Proteins chosen for validation.

Protein ID	Gene symbol	Proteins	Unique peptides	Average iTRAQ ratio (I/C)	p value	Main function
Q642G4	Peroxisomal membrane protein Pex14	1	1	0.2805	0.011	An essential component of the peroxisomal import machinery. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Q6IN39	Peroxisomal multifunctional enzyme type 2 Hsd17b4	2	6	0.5702	0.05	Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids.
D3ZVU7	Histone deacetylase1	3	3	0.4278	0.0053	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4).
P39951	Cyclin-dependent kinase 1	19	3	0.5939	0.0223	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset
D3ZP96	DNA helicase MCM2	1	3	0.5621	0.0033	A component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for “once per cell cycle” DNA replication initiation and elongation in eukaryotic cells. Plays a role in cell apoptosis.
B2GUX3	DNA helicase MCM5	3	6	2.0485	0.0283	A component of the MCM2-7 complex. Interacts with MCMBP.
Have/no
D3ZGX8	Bromodomain-containing 4	2	1	None	Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation.
F1LQB2	Structural maintenance of chromosomes protein Smc3	3	5	None	Central component of cohesin, a complex required for chromosome cohesion during the cell cycle.
Q08420	Extracellular superoxide dismutase [Cu-Zn]SOD3	1	1	Have	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

C: control; I: IUGR; peptide: the number of peptides identified by LC-MS/MS.