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. 2019 Nov 3;2019:7536803. doi: 10.1155/2019/7536803

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Copyright © 2019 Qing-Qing Wu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zileuton regulates PPARα/NRF2 signaling. (a, b) Protein expression levels of PPARα, PPARγ, and PPARƍ in mouse hearts 8 weeks after AB surgery and 7 weeks after zileuton administration (100 mg/kg/d, orally) (n = 6). (c, d) Protein expression levels of keap1, PGC1-α, NRF2, and nuclear-NRF2 in mouse hearts (n = 6). ^∗P < 0.05 vs. the vehicle-sham group; ^#P < 0.05 vs. the vehicle-AB group. (e, f) Protein expression levels of PPARα, NRF2, and nuclear-NRF2 in H9c2 cells (n = 6) after 24 h of PE (50 μM) stimulation and zileuton (100 μM) treatment ^∗P < 0.05 vs. the control group; ^#P < 0.05 vs. the PE group.