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. 2019 Nov 3;2019:7536803. doi: 10.1155/2019/7536803

Figure 8.

Figure 8

PPARα knockdown blunts zileuton's antihypertrophic effect in vivo. Mice were subjected to AAV9-shPPARα injection. Two weeks after injection, the mice were subjected to AB surgery. One week after AB, the mice were treated with zileuton (100 mg/kg/d) for 7 weeks. (a) PPARα levels in the heart 10 weeks after AAV9-shPPARα injection (n = 6). (b) HW/BW, HW/TL, LW/BW and LW/TL ratios in mice (n = 12). (c, d) HE staining (n = 6) and quantification results in mice (n > 50 cells). ∗P < 0.05 vs. the vehicle-sham group; #P < 0.05 vs. the vehicle-AB group.