Table 2.
The list of top 10 neoantigens, their corresponding mutation (AA change), neoantigen frequency in Fujian and TCGA cohorts (Freq1, n = 482), mutation frequency in all GC cohort (Freq2, n = 942), and TCGA pan-cancer cohort (Freq3, n = 11,160), and HLA information.
| Gene | AA change | Freq1 | Freq2 | Freq3 | HLA types |
|---|---|---|---|---|---|
| PGM5 | I98V | 10 | 26 | 51 | HLA-A02:30; HLA-A02:01; HLA-A02:03; HLA-A02:05; HLA-A02:06; HLA-A02:07; HLA-C03:03 |
| TP53 | R175H | 8 | 25 | 162 | HLA-C07:02; HLA-C07:01; HLA-A68:01; HLA-A02:03 |
| TRIM49C | S327R | 7 | 10 | 17 | HLA-B35:03; HLA-C06:02; HLA-C12:03; HLA-C07:01; HLA-C07:02; HLA-B27:08; HLA-B07:02; HLA-A02:01; HLA-B27:05; HLA-B57:01; HLA-A32:01; HLA-A11:01; HLA-A31:01 |
| PIK3CA | H1047R | 5 | 24 | 298 | HLA-C07:02; HLA-C07:01; HLA-A30:01; HLA-B58:01; HLA-B57:01; HLA-A33:03; HLA-A68:01 |
| TP53 | R273H | 5 | 16 | 145 | HLA-A02:01; HLA-A02:07; HLA-A02:17; HLA-A68:01 |
| KRAS | G13D | 5 | 15 | 78 | HLA-A02:01; HLA-A11:01; HLA-A68:01 |
| ERBB3 | V104M | 5 | 11 | 33 | HLA-C06:02; HLA-B08:01; HLA-C07:01; HLA-A30:01; HLA-C12:03; HLA-B35:01; HLA-A30:02; HLA-A68:01; HLA-B07:02; HLA-A03:01; HLA-C07:02; HLA-A02:01 |
| C6 | K817T | 4 | 5 | 9 | HLA-C03:04; HLA-C07:01; HLA-C03:03; HLA-C12:02; HLA-A02:01; HLA-C02:10; HLA-A24:02; HLA-B35:01; HLA-B15:03; HLA-A31:01 |
| KRAS | G12D | 4 | 16 | 430 | HLA-A02:01; HLA-C05:01; HLA-A02:06; HLA-A11:01; HLA-A03:01; HLA-B07:02 |
| TP53 | R282W | 4 | 14 | 97 | HLA-C03:03; HLA-A11:01; HLA-A03:01; HLA-B07:02; HLA-A68:01 |
| OR4C16 | S135R | 4 | 6 | 8 | HLA-B37:01; HLA-A02:06; HLA-A02:01; HLA-B15:01; HLA-C03:03; HLA-B27:05; HLA-A03:01; HLA-C07:02; HLA-A24:02 |