Table 3.
Genotypic and allelic association of single-nucleotide polymorphisms (SNPs) in miRNAs with ischemic stroke.
| Gene/SNP/location | Model/allele | Genotype | Con | IS | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| miRNA-933 | Additive | G/G | 335 (73.8) | 181 (68.8) | 1 | |
| rs79402775 | G/A | 110 (24.2) | 75 (28.5) | |||
| Chr 2 | A/A | 9 (2.0) | 7 (2.7) | 1.59 (1.10-2.31) | 0.016 | |
| Dominant | G/G | 335 (73.8) | 181 (68.8) | 1 | ||
| G/A-A/A | 119 (26.2) | 82 (31.2) | 1.65 (1.08-2.53) | 0.022 | ||
| Recessive | G/G-G/A | 445 (98.0) | 256 (97.3) | 1 | ||
| A/A | 9 (2.0) | 7 (2.7) | 2.22 (0.68-7.26) | 0.20 | ||
| Allele | G | 780 (85.9) | 437 (83.1) | 1 | ||
| A | 128 (14.1) | 89 (16.9) | 1.24 (0.92-1.67) | 0.15 | ||
| miRNA-146A | Additive | C/C | 182 (40.4) | 110 (41.7) | 1 | |
| rs2910164 | C/G | 208 (46.1) | 115 (43.6) | |||
| Chr 5 | G/G | 61 (13.5) | 39 (14.8) | 1.04 (0.82-1.31) | 0.75 | |
| Dominant | C/C | 182 (40.4) | 110 (41.7) | 1 | ||
| C/G-G/G | 269 (59.6) | 154 (58.3) | 1.01 (0.73-1.40) | 0.96 | ||
| Recessive | C/C-C/G | 390 (86.5) | 225 (85.2) | 1 | ||
| G/G | 61 (13.5) | 39 (14.8) | 1.14 (0.72-1.80) | 0.59 | ||
| Allele | C | 572 (63.4) | 335 (63.4) | 1 | ||
| G | 330 (36.6) | 193 (36.6) | 1.00 (0.80-1.25) | 0.99 | ||
| miRNA-4669 | Additive | A/A | 200 (44.0) | 155 (58.7) | 1 | |
| rs35196866 | A/C | 206 (45.3) | 89 (33.7) | |||
| Chr 9 | C/C | 49 (10.8) | 20 (7.6) | 0.66 (0.52-0.86) | 0.0014 | |
| Dominant | A/A | 200 (44.0) | 155 (58.7) | 1 | ||
| A/C-C/C | 255 (56.0) | 109 (41.3) | 0.57 (0.41-0.79) | 0.00015 | ||
| Recessive | A/A-A/C | 406 (89.2) | 244 (92.4) | 1 | ||
| C/C | 49 (10.8) | 20 (7.6) | 0.67 (0.38-1.18) | 0.16 | ||
| Allele | A | 606 (66.6) | 399 (75.6) | 1 | ||
| C | 304 (33.4) | 129 (24.4) | 0.64 (0.51-0.82) | 0.00037 | ||
| miRNA-196A2 | Additive | T/T | 139 (30.6) | 85 (32.3) | 1 | |
| rs11614913 | C/T | 209 (45.9) | 108 (41.1) | |||
| Chr 12 | C/C | 107 (23.5) | 70 (26.6) | 1.03 (0.83-1.28) | 0.79 | |
| Dominant | T/T | 139 (30.6) | 85 (32.3) | 1 | ||
| C/T-C/C | 316 (69.5) | 178 (67.7) | 0.91 (0.64-1.29) | 0.60 | ||
| Recessive | T/T-C/T | 348 (76.5) | 193 (73.4) | 1 | ||
| C/C | 107 (23.5) | 70 (26.6) | 1.22 (0.84-1.77) | 0.30 | ||
| Allele | T | 487 (53.5) | 278 (52.9) | 1 | ||
| C | 423 (46.5) | 248 (47.1) | 1.03 (0.83-1.27) | 0.81 | ||
| miRNA-499A | Additive | A/A | 321 (70.5) | 173 (65.8) | 1 | |
| rs3746444 | A/G | 122 (26.8) | 76 (28.9) | |||
| Chr 20 | G/G | 12 (2.6) | 14 (5.3) | 1.28 (0.96-1.70) | 0.10 | |
| Dominant | A/A | 321 (70.5) | 173 (65.8) | 1 | ||
| A/G-G/G | 134 (29.4) | 90 (34.2) | 1.26 (0.89-1.78) | 0.19 | ||
| Recessive | A/A-A/G | 443 (97.4) | 249 (94.7) | 1 | ||
| G/G | 12 (2.6) | 14 (5.3) | 1.91 (0.84-4.36) | 0.12 | ||
| Allele | A | 764 (84.0) | 422 (80.2) | 1 | ||
| G | 146 (16.0) | 104 (19.8) | 1.29 (0.98-1.70) | 0.07 | ||
| miRNA-2117 | Additive | T/T | 222 (49.0) | 124 (47.1) | 1 | |
| rs7207008 | T/A | 198 (43.7) | 100 (38.0) | |||
| Chr 17 | A/A | 33 (7.3) | 39 (14.8) | 1.35 (1.00-1.82) | 0.049 | |
| Dominant | T/T | 222 (49.0) | 124 (47.1) | 1 | ||
| T/A-A/A | 231 (51.0) | 139 (52.9) | 1.22 (0.82-1.81) | 0.33 | ||
| Recessive | T/T-T/A | 420 (92.7) | 224 (85.2) | 1 | ||
| A/A | 33 (7.3) | 39 (14.8) | 2.32 (1.26-4.26) | 0.0084 | ||
| Allele | T | 642 (70.9) | 348 (66.2) | 1 | ||
| A | 264 (29.1) | 178 (33.8) | 1.24 (0.99-1.57) | 0.06 |
Bold characters represent statistically significant values after Bonferroni correction (p < 0.05/6).