Table 3.
L-dopa prescribing ratea | COMT inhibitors prescribing rate | All DAs prescribing rate | MAO-B inhibitors prescribing rate | Amantadine prescribing rate | Anticholinergics prescribing rate | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median | Range | P valuea | Median | Range | P value | Median | Range | P value | Median | Range | P value | Median | Range | P value | Median | Range | P value | |
Quality score | ||||||||||||||||||
(1–3) | 37.38 | 26–48.76 | 0.091 | 3.58 | 3.53–3.63 | 0.245 | 36.73 | 11.20–62.26 | 0.825 | 5.57 | 3.88–7.27 | 0.575 | 6.71 | NA (one study only) | 0.895 | 25.44 | NA (one study only) | 0.285 |
(4–6) | 70.92 | 21–100 | 4.80 | 0.24–13.31 | 26.45 | 9.21–76.92 | 10.81 | 2.10–31 | 5.46 | 1.10–44.23 | 5.46 | 2.91–43 | ||||||
>6 | 87.17 | 51–98.50 | 6.80 | 3.10–10.10 | 28.75 | 7.63–75 | 10.50 | 1.67–21 | 5.14 | 0.80–22.10 | 5.14 | 3.81–31.40 | ||||||
Source of data | ||||||||||||||||||
Insurance-claims, prescription registries, or drug sales databases | 53.78 | 21–90 | 0.009 b | 5.61 | 1–13.31 | 0.245 | 29 | 9.21–75 | 0.825 | 9.63 | 2.10–24.60 | 0.575 | 6.58 | 1.10–22.10 | 0.895 | 18.18 | 2.91–43 | 0.285 |
Medical charts and administrative databases | 83.60 | 43.73–94.80 | 6 | 0.24–10.10 | 25 | 7.63–32.04 | 8.90 | 1.67–21 | 5.10 | 2–17.20 | 22.90 | 3.81–40.40 | ||||||
Patients' interviews, questionnaires, or surveys | 90.40 | 78.84–100 | 4 | 3.10–5.80 | 43.70 | 18–76.92 | 11.08 | 2.30–31 | 5 | 0.80–44.23 | 19.80 | 8.50–30.76 |
aTest based on Kruskal–Wallis statistic, significance level at P < 0.05. bPost hoc analysis: insurance-claims, prescription registries, or drug sales databases vs medical charts and administrative databases P=0.234. Insurance-claims, prescription registries, or drug sales databases vs patients' interviews, questionnaires, or surveys, P=0.011. Medical charts and administrative databases vs patients' interviews, questionnaires, or surveys P=0.582.