Table 7.
MAs outcomes about adverse events.
| Study ID | Outcome | Acute or preventive treatment | Intervention | Control | Follow-up time | RCTs (n) | I2 | Model | Scale | Effect | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Linde et al. [14] | Number of patients reporting adverse effects | ND | Acupuncture | ② | NR | 4 (838) | 73% | FEM | OR | 0.47 | [0.34, 0.65] | <0.00001 |
| Number of patients dropping out due to adverse effects | NR | 2 (191) | 0% | FEM | OR | 0.10 | [0.01, 0.78] | 0.028 | ||||
|
| ||||||||||||
| Linde et al. [7] | Number of participants dropping out due to adverse effects | Preventive treatment | Acupuncture | ① | NR | 7 (931) | 0% | FEM | OR | 2.84 | [0.43, 18.71] | 0.28 |
| Number of participants reporting adverse effects | 4 (1414) | 0% | FEM | OR | 1.15 | [0.85, 1.56] | 0.35 | |||||
| Number of participants with serious adverse events | 6 (1071) | 0% | FEM | OR | 1.29 | [0.43, 3.83] | 0.65 | |||||
| Number of participants dropping out due to adverse effects | ② | NR | 4 (451) | 0% | REM | OR | 0.27 | [0.08, 0.86] | 0.027 | |||
| Number of participants reporting adverse effects | 5 (931) | 78% | REM | OR | 0.25 | [0.10, 0.62] | 0.0027 | |||||
| Number of participants with serious adverse events | 3 (721) | 0% | REM | OR | 1.33 | [0.38, 4.73] | 0.66 | |||||
|
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| Chen [16] | Number of adverse effects | ND | Acupuncture | ND | NR | 5 (567) | 0% | FEM | RR | 0.11 | [0.03, 0.49] | 0.003 |
|
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| Pu [24] | Rate of adverse events | Preventive treatment | Acupuncture | ② | NR | 7 (1126) | 77% | REM | RR | 0.33 | [0.17, 0.64] | 0.001 |
∗NR: not reported; ND: not defined; ①: sham acupuncture; ②: drug treatment; FEM: fixed effects model; REM: random effects model.