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miR-200a reduced oxidative stress in DOX-treated mice: (a) the level of MMP2 and MMP9 in the hearts (n = 6); (b) the level of TNF-α and IL-6 in the hearts (n = 6); (c, d) the levels of GSH and cardiac MDA in the hearts (n = 6); (e) the level of 4-HNE in the hearts (n = 6); (f) the level of SOD2 mRNA in the hearts (n = 6); (g) protein expression of Nrf2 and HO-1 (n = 6). ∗P < 0.05 compared with the group with saline. #P < 0.05 compared with mice after DOX injection.
