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miR-200a could not provide cardiac protection against DOX-induced acute cardiotoxicity in Nrf2-deficient mice: (a) schedule of Nrf2 deficiency in mice with the acute DOX treatment; (b) the level of Nrf2 in the hearts (n = 6); (c) EF (n = 8); (d, e) the levels of NT-proBNP and MDA in the hearts (n = 6); (f) caspase 3 activity (n = 6). ∗P < 0.05.
