. 2019 Nov 12;2019:1468502. doi: 10.1155/2019/1468502

Table 2.

Effects of noreugenin (NRG) and α-hydroxy-butein (AH-BU) on antioxidant enzyme activities and TBARS concentration in carrageenan-induced inflammation in the mouse model of pleurisy.

Groups/dose (mg/kg)	CAT (mmol/min/mL) (% of inhibition)	SOD (USOD/mL) (% of inhibition)	GST (μmol/min/mL) (% of inhibition)	TBARS (mmol/mL) (% of inhibition)
Sal^a	10.91 ± 1.20	31.45 ± 3.73	6.90 ± 1.10	2.81 ± 0.21
Cg^a	31.61 ± 4.22	63.75 ± 3.19	16.36 ± 0.59	10.64 ± 0.58
Dex (0.5)^b	14.05 ± 0.63(55.54±1.99)^∗∗	40.90 ± 3.63(35.84 ± 5.70)^∗	9.57 ± 0.74(41.49±4.52)^∗∗	4.13 ± 0.85(61.18±7.96)^∗∗
NRG (5)^b	12.04 ± 1.23(61.93±3.88)^∗∗	39.55 ± 4.09(37.96 ± 6.42)^∗	4.23 ± 0.29(74.15±1.80)^∗∗	5.88 ± 0.96(44.72±9.02)^∗∗
AH-BU (2.5)^b	13.23 ± 2.13(58.16±6.74)^∗∗	26.43 ± 5.68(58.55±8.91)^∗∗	5.31 ± 0.94(67.56±5.74)^∗∗	6.00 ± 0.57(43.61 ± 5.36)^∗

CAT: catalase; SOD: superoxide dismutase; GST: glutathione S-transferase; TBARS: thiobarbituric acid reactive substances. Noreugenin (NRG: 5 mg/kg) and α-hydroxy-butein (AH-BU: 2.5 mg/kg) administered 0.5 h before pleurisy induction by carrageenan (1%). Sal = animals treated with sterile saline solution (NaCl 0.9%) only. Cg = animals treated with carrageenan (1%) only. Dex = animals pretreated with dexamethasone (0.5 mg/kg). ^aAdministered by intrapleural injection (i.pl.). ^bAdministered by intraperitoneal route (i.p.). Each group represents the mean ± S.E.M. of 5 animals. ^∗p < 0.05 and ^∗∗p < 0.01 compared to the positive control group (Cg); ANOVA/Newman–Keuls test.