Figure 1.

Effects of different drugs on cells. ^ap < 0.05,^a∗p < 0.01,^a∗∗p < 0.001, compared with control group; ^bp < 0.05,^b∗p < 0.01,^b∗∗p < 0.001, compared with OXA group; ^cp < 0.05,^c∗p < 0.01,^c∗∗p < 0.001, compared with RT group; ^dp < 0.05,^d∗p < 0.01,^d∗∗p < 0.001, compared with combination of OXA and RT. Control: SGC-7901/NGEC; SB203580 : 15 nM; RT: 300 μM; OXA:33 μM; RT + OXA: (300 μM + 33 μM); RT + SB203580 (300 μM + 15 nM); RT + OXA + SB203580: (300 μM + 33 μM+15 nM). (a, b) Effect of different concentrations of RT and OXA on the toxicity of NGEC cells and the viability of SGC-7901 cells by MTT ($\overline{X}\pm S$, n = 6). (c) Effects of p38 inhibitor, RT, OXA, and drug combination on SGC-7901 cells proliferation assessed by MTT ($\overline{X}$ ± S, n = 6). (d) Morphological observation of SGC-7901 cells (Hoechst33258, ×200).