Table 2.
Genotype and allele frequencies of MSX1, PAX9, and AXIN2 polymorphisms in the local population.
| Polymorphism | Agenesis: all cases (N = 97), n | Controls (N = 99), n | Statistical analysis for genotypes | Statistical analysis for alleles |
|---|---|---|---|---|
| MSX1 rs12532 A/G | ||||
| A/A | 50 | 45 | A/G + G/G vs A/A | G vs A |
| A/G | 37 | 42 | Chi-square = 0.5 | Chi-square = 0.53 |
| G/G | 10 | 12 | p=0.477 | p=0.462 |
| A | 137 | 132 | OR = 0.78 | OR = 0.83 |
| G | 57 | 66 | ||
|
| ||||
| MSX1 rs8670 C/T | ||||
| C/C | 49 | 74 | C/T + T/T vs C/C | T vs C |
| C/T | 37 | 22 | Chi-square = 11.24 | Chi-square = 14.09 |
| T/T | 11 | 3 | p=0.0008∗ | p=0.0002∗ |
| C | 135 | 170 | OR = 2.9 | OR = 2.65 |
| T | 59 | 28 | ||
|
| ||||
| PAX9 rs61754301 C/T | ||||
| C/C | 97 | 99 | C/T + T/T vs C/C | T vs C |
| C/T | 0 | 0 | ||
| T/T | 0 | 0 | NA | NA |
| C | 194 | 198 | ||
| T | 0 | 0 | ||
|
| ||||
| PAX9 rs4904155 C/G | ||||
| C/C | 40 | 50 | C/G + G/G vs C/C | G vs C |
| C/G | 43 | 34 | Chi-square = 1.34 | Chi-square = 0.61 |
| G/G | 14 | 15 | p=0.246 | p=0.432 |
| C | 123 | 134 | OR = 1.45 | OR = 1.2 |
| G | 71 | 64 | ||
|
| ||||
| AXIN2 rs2240308 G/A | ||||
| G/G | 18 | 24 | G/A + A/A vs G/G | A vs G |
| G/A | 49 | 55 | Chi-square = 0.63 | Chi-square = 2.32 |
| A/A | 30 | 20 | p=0.426 | p=0.127 |
| G | 85 | 103 | OR = 1.4 | OR = 1.39 |
| A | 109 | 95 | ||
p ≤ 0.001, highly significant; 0.001 ≤ p ≤ 0.05, significant; p ≥ 0.05, not significant; NA, not available.