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. 2019 Nov 6;2019:2197017. doi: 10.1155/2019/2197017

Figure 2.

Figure 2

LXA4 inhibited proinflammatory cytokine and ROS generation in AP-ALI mice. Mouse serum and lung tissue samples were collected to evaluate injury 24 h after modeling. (a–c) The serum levels of the inflammatory factors TNF-α, IL-1β, and E-selectin were measured by ELISA. (d) Immunohistochemistry micrographs of lung tissue sections show the expression of IL-6. (e) Flow cytometric analysis of the cellular ROS in lung tissues in different experimental mouse groups was performed. (f) The quantitative mean fluorescence intensity in each treatment group is shown. ∗P < 0.05 and ∗∗P < 0.01 vs. the control group. #P < 0.05 and ##P < 0.01 vs. the AP group. AP: the acute pancreatitis group; AP+LXA4: the acute pancreatitis+Lipoxin A4 group; AP-ALI: the acute pancreatitis-induced acute lung injury; ROS: reactive oxygen species.