Table 6.
Risk for malignant tumors.
| Malignancy | Cases (adrenocortical tumor) | Controls (normal adrenal) | OR (95% CI) | AOR (95% CI)∗ |
|---|---|---|---|---|
| Gastrointestinal cancer | 22 (5.5%) | 29 (7.3%) | 0.74 (0.42, 1.32) | 0.84 (0.42, 1.69) |
| Renal/bladder cancer | 14 (3.5%) | 18 (4.5%) | 0.77 (0.38, 1.57) | 0.98 (0.41, 2.33) |
| Breast cancer | 36 (9.0%) | 50 (12.5%) | 0.69 (0.44, 1.08) | 0.83 (0.47, 1.46) |
| Lung cancer | 23 (5.8%) | 12 (3.0%) | 2.0 (0.97, 4.02) | 1.73 (0.77, 4.10) |
| Brain cancer | 2 (0.5%) | 4 (1.0%) | 0.45 (0.09, 2.73) | NA |
| Endocrine cancer | 13 (3.3%) | 11 (2.8%) | 1.28 (0.53, 2.68) | 1.53 (0.60, 4.11) |
| Hematologic cancer | 15 (3.8%) | 24 (6.0%) | 0.61 (0.31, 1.18) | 0.59 (0.27, 1.25) |
| Melanoma/sarcoma | 4 (1.0%) | 14 (3.5%) | 0.28 (0.09, 0.85) | 0.19 (0.05, 0.59) |
| Gynecologic cancer | 15 (3.7%) | 20 (5.0%) | 0.74 (0.37, 1.47) | 0.57 (0.24, 1.26) |
| Prostate/testicular cancer | 13 (3.2%) | 16 (4%) | 0.80 (0.38, 1.70) | 0.49 (0.16, 1.50) |
| Other cancer | 3 (0.8%) | 2 (0.5%) | 1.50 (0.25, 9.04) | NA |
Note. The unadjusted and adjusted∗ odds ratio for patients with benign adrenocortical tumors (cases) compared with those with normal adrenal glands (controls) are presented along with 95% confidence intervals for each malignancy. AOR: adjusted odds ratio; ∗adjusted for age, sex, race, smoking status, BMI, duration imaging interval, hypertension, hyperlipidemia, composite diabetes (diabetes or prediabetes), coronary artery disease, and myocardial infarction.