Table 2.
Allelic and genotypic association of SNPs in the case-control study using logistic regression.
| SNPs | Allele | Allele gene | Genotype count | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 1/2 | 1/2 | 1/2 | OR | P | 11/12/22 | 11/12/22 | OR | P | |
| Case | Control | (95% CI) | Case | Control | (95% CI) | ||||
| Obesity: normal weight | |||||||||
| rs2331841 | A/G | 276/842 | 198/722 | 1.21 (0.98, 1.50) | 0.07 | 38/200/321 | 18/162/280 | 1.38 (1.03, 1.85) | 0.032 |
| rs6567160 | C/T | 262/858 | 193/729 | 1.16 (0.94, 1.44) | 0.17 | 33/196/331 | 17/159/285 | 1.30 (0.96, 1.77) | 0.089 |
| rs571312 | A/C | 259/859 | 189/725 | 1.16 (0.94, 1.44) | 0.17 | 32/195/332 | 17/155/285 | 1.28 (0.94, 1.73) | 0.12 |
| rs17782313 | C/T | 259/859 | 193/727 | 1.14 (0.92, 1.41) | 0.22 | 34/191/334 | 18/157/285 | 1.28 (0.95, 1.72) | 0.11 |
| rs12970134 | A/G | 228/888 | 180/742 | 1.07 (0.86, 1.34) | 0.55 | 24/180/354 | 11/158/292 | 1.37 (0.95, 1.98) | 0.093 |
| rs11872992 | A/G | 233/887 | 207/713 | 0.90 (0.73, 1.11) | 0.31 | 32/169/359 | 24/159/277 | 1.00 (0.76, 1.32) | 0.99 |
|
| |||||||||
| Obesity: metabolic healthy normal weight (MH-NW) | |||||||||
| rs2331841 | A/G | 234/676 | 120/450 | 1.32 (1.02, 1.69) | 0.034 | 31/172/252 | 12/96/177 | 1.35 (1.92, 0.96) | 0.08 |
| rs6567160 | C/T | 224/686 | 118/454 | 1.27 (0.98, 1.64) | 0.065 | 27/170/258 | 11/96/179 | 1.32 (0.92, 1.89) | 0.14 |
| rs571312 | A/C | 220/686 | 116/452 | 1.27 (0.98, 1.64) | 0.074 | 26/168/259 | 11/94/179 | 1.28 (0.89, 1.92) | 0.17 |
| rs17782313 | C/T | 223/687 | 118/452 | 1.25 (0.97, 1.61) | 0.079 | 28/167/260 | 12/94/179 | 1.28 (0.90, 1.82) | 0.17 |
| rs12970134 | A/G | 196/714 | 115/457 | 1.10 (0.85, 1.43) | 0.47 | 20/156/279 | 8/99/179 | 1.28 (0.84, 1.96) | 0.25 |
| rs11872992 | A/G | 201/709 | 123/447 | 1.02 (0.79, 1.30) | 0.89 | 30/141/284 | 11/101/173 | 1.27 (0.88, 1.82) | 0.2 |
|
| |||||||||
| Metabolically unhealthy obesity (MUHO): metabolic healthy normal weight (MH-NW) | |||||||||
| rs2331841 | A/G | 156/404 | 120/450 | 1.49 (1.14, 1.96) | 0.005 a | 25/106/149 | 12/96/177 | 1.64 (1.14, 2.38) | 0.008 |
| rs6567160 | C/T | 149/411 | 118/454 | 1.45 (1.09, 1.92) | 0.011 a | 21/107/152 | 11/96/179 | 1.54 (1.05, 2.27) | 0.026 |
| rs571312 | A/C | 147/413 | 116/452 | 1.43 (1.08, 1.89) | 0.013 a | 20/107/153 | 11/94/179 | 1.49 (1.02, 2.22) | 0.041 |
| rs17782313 | C/T | 148/412 | 118/452 | 1.41 (1.06, 1.67) | 0.015 a | 22/104/154 | 12/94/179 | 1.52 (1.04, 2.17) | 0.03 |
| rs12970134 | A/G | 131/429 | 115/457 | 1.25 (0.93, 1.67) | 0.14 | 17/97/166 | 8/99/179 | 1.56 (1.01, 2.48) | 0.048 |
| rs11872992 | A/G | 117/443 | 123/447 | 0.93 (0.70, 1.23) | 0.61 | 17/83/180 | 11/101/173 | 1.18 (0.79, 1.75) | 0.43 |
|
| |||||||||
| Metabolically unhealthy obesity (MUHO): metabolically healthy obesity (MHO) | |||||||||
| rs2331841 | A/G | 78/272 | 156/404 | 1.39 (1.02, 1.92) | 0.039 | 6/66/103 | 25/106/149 | 1.75 (1.10, 2.78) | 0.017 |
| rs6567160 | C/T | 75/275 | 149/411 | 1.37 (0.99, 1.89) | 0.056 | 6/63/106 | 21/107/152 | 1.56 (0.98, 2.50) | 0.052 |
| rs571312 | A/C | 73/273 | 147/413 | 1.36 (0.98, 1.89) | 0.063 | 6/61/106 | 20/107/153 | 1.52 (0.95, 2.44) | 0.078 |
| rs17782313 | C/T | 75/275 | 148/412 | 1.36 (0.98, 1.87) | 0.065 | 6/63/106 | 22/104/154 | 1.59 (0.99, 2.56) | 0.044 |
| rs12970134 | A/G | 65/285 | 131/429 | 1.37 (0.97, 1.92) | 0.070 | 3/59/113 | 17/97/166 | 1.96 (1.05, 3.67) | 0.027 |
| rs11872992 | A/G | 84/266 | 117/443 | 0.84 (0.62, 1.14) | 0.27 | 13/58/104 | 17/83/180 | 0.87 (0.59, 1.078) | 0.36 |
aRemain significant after false discovery rate (FDR) analysis.