Table 6.
Associations of SNPs in MC4R gene with DBP in all subjects.
| SNP variables | Genotype | P ∗ | P # | P Δ | ||
|---|---|---|---|---|---|---|
| rs2331841 | AA | AG | GG | |||
| DBP (mmHg) | 82.06 (78.70, 85.42) | 82.92 (81.42, 84.41) | 80.44 (79.34, 81.54) | 0.023 | 0.033 | 0.059 |
|
| ||||||
| rs6567160 | CC | CT | TT | |||
| DBP (mmHg) | 81.40 (77.94, 84.86) | 83.20 (81.70, 84.70) | 80.36 (79.27, 81.45) | 0.011 | 0.014 | 0.030 |
|
| ||||||
| rs571312 | AA | AC | CC | |||
| DBP (mmHg) | 81.88 (78.22, 85.54) | 83.24 (81.72, 84.76) | 80.36 (79.27, 81.45) | 0.012 | 0.013 | 0.033 |
|
| ||||||
| rs17782313 | CC | CT | TT | |||
| DBP (mmHg) | 80.40 (79.32, 81.49) | 83.15 (81.63, 84.68) | 81.81 (78.34, 85.27) | 0.020 | 0.021 | 0.047 |
|
| ||||||
| rs12970134 | AA | AG | GG | |||
| DBP (mmHg) | 81.38 (76.48, 86.27) | 82.86 (81.29, 84.42) | 80.66 (79.60, 81.72) | 0.033 | 0.034 | 0.151 |
|
| ||||||
| rs11872992 | AA | AG | GG | |||
| DBP (mmHg) | 81.46 (78.36, 84.24) | 82.23 (81.01, 83.45) | 80.98 (79.21, 82.68) | 0.164 | 0.270 | 0.830 |
∗ANOVA (one-way analysis of variance) analysis between three genotypes. #Comparison of the genotypes under the dominant model. ΔLogistic regression analysis between three genotypes and DBP after adjusting for sex, age, and BMI. DBP: diastolic blood pressure.