Table 4.
Univariate and multivariate Cox regression analyses for overall survival in patients with adenocarcinoma of oesophagogastric junction (matched datasets, 1 : 1).
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | ||||
| Female vs. male | 1.16 (0.72-1.84) | 0.540 | — | — |
| Age | ||||
| >60 vs. ≤60 | 1.09 (0.74-1.62) | 0.656 | — | — |
| Grade | 0.043∗ | 0.491 | ||
| Well | Ref. | Ref. | ||
| Moderately | 4.56 (1.12-18.56) | 0.034∗ | 1.71 (0.38-7.67) | 0.486 |
| Poorly | 5.23 (1.25-21.99) | 0.024∗ | 1.35 (0.29-6.36) | 0.703 |
| Tumour size | ||||
| >5 cm vs. ≤5 cm | 1.52 (1.04-1.98) | 0.041∗ | 1.01 (0.66-1.54) | 0.96 |
| AJCC TNM stage | <0.001∗ | <0.001∗ | ||
| I | Ref. | Ref. | ||
| II | 1.92 (0.99-3.71) | 0.053 | 1.77 (0.88-3.56) | 0.107 |
| III | 6.01 (3.36-10.74) | <0.001∗ | 4.97 (2.61-9.46) | <0.001∗ |
| Vascular invasion | ||||
| Yes vs. no | 4.50 (2.58-7.88) | <0.001∗ | 2.38 (1.32-4.29) | 0.004∗ |
| SIRI | ||||
| >0.68 vs. ≤0.68 | 1.67 (1.13-2.47) | 0.010∗ | 1.51 (1.02-2.24) | 0.040∗ |
AJCC: American Joint Committee on Cancer; SIRI: systemic inflammation response index; HR: hazard ratio; CI: confidence interval; Ref.: reference.