Table 2. Analysis of risk factors for refractoriness.
| No. of subjects (n = 130) | Controlled group (n = 76) | Refractory group (n = 54) | Multi-variate P value (hazard ratio) |
|---|---|---|---|
| Sex (female) | 16 (21.1) | 16 (29.6) | |
| Age (yr) | 54 (48–61) | 44 (34–58) | 0.015 (0.96) |
| Atopic (number) | 33 (43.4) | 25 (49.0) | |
| Asthma (number) | 7 (9.2) | 10 (18.5) | |
| Symptom duration (mon) | 30 (6–120) | 60 (18–120) | |
| Lund-Mackay score | 14 (11–18) | 19 (13–22) | 0.004 (1.14) |
| Global-osteitis score | 10 (5–17) | 20 (9–24) | |
| Butanol threshold test | 4 (0–8) | 2 (0–7) | |
| Tissue eosinophil count (cells/HPF) | 10.0 (2.3–40.7) | 25.5 (4.1–92.0) | 0.014 (1.01) |
| Tissue eosinophilia (≥ 70 cells/HPF) | 16 (21.1) | 20 (37.0) | |
| Tissue neutrophil count (cells/HPF) | 11.9 (6.0–23.5) | 24.0 (8.9–59.86) | |
| Tissue neutrophilia (≥ 20 cells/HPF) | 26 (34.2) | 31 (57.4) | 0.001 (4.38) |
| Current smoking (number) | 22 (28.9) | 18 (33.3) | |
| Smoking history (pack/year) | 0 (0–10) | 0 (0–5) | |
| Alcohol intake (g/mon) | 56 (0–488) | 10 (0–280) | |
| BMI (kg/m2) | 24.6 (22.5–26.4) | 23.6 (21.5–25.2) |
Value is presented as number (%) or median with interquartile range. Bold text indicates statistical significance (P < 0.05).
BTT, butanol threshold test; HPF, high power field; BMI, body mass index