Table 4. miRs are up- and down-regulated in PBMCs of asthmatic subjects compared to healthy controls after virus infection (RSV and IFV).

Virus type	miR	Regulation in asthmatics	Role/pathway/target	Reference
RSV	miR-320e	↓	Pathways: inflammatory, immune response, Wnt, TGF-β, insulin, and T- and B-cell receptor signalling	100
	miR-320d	↓	-	100
	miR-877-5p	↓	-	100
	miR-122-5p	↓	-	100
	miR-92b-5p	↓	-	100
	miR-106b-5p	↑	-	100
	miR-20b-5p	↑	-	100
	miR-342-3p	↑	-	100
	miR-26b	↑	Target: TLR4, IFN-β, CCL5	99
IFV	miR-26a	↓	Target: IFN-α/β	106
	miR-650	↓	Pathway: innate immunity	101
			Target: IFIT2, MXA
	miR-451a	↑	Pathway: type I IFN	102
			Target: IL-6
	miR-3123	↑	-	104
	miR-342-5p	↑	Pathway: sterol biosynthesis	105

PBMC, peripheral blood mononuclear cell; RSV, respiratory syncytial virus; IFV, influenza virus.