Figure 2.

Derivation of the PT‐adjustment function. Relationship between the PT covariate and observed prediction‐corrected exposure estimates for (a) AUC _0–24, (b) C_max, and (c) C_trough. (d) Comparison of the linear PT‐adjustment functions for AUC _0–24, C_max, and C_trough. Blue shading shows the 95% confidence bound for the locally estimated scatterplot smoothing regression. Dotted boxes highlight areas where 95% of the data are located. Solid colored lines show the respective estimated linear relationship. AUC _0–24, area under the plasma concentration–time curve over 24 hours; C_max, maximum concentration; C_trough, trough concentration at the end of the dosing interval before the next dose; PT, prothrombin time.