. 2019 Jul 5;8(11):805–814. doi: 10.1002/psp4.12444

Table 2.

Regression of prediction‐corrected exposure metric and PT covariate exposure (intercept and slope)

Exposure measure		Estimate	Lower CI	Upper CI	P value
AUC_0–24, μg*L/hour	Intercept	–0.0147	–0.117	0.088	0.778
AUC_0–24, μg*L/hour	Slope	1.02	0.924	1.120	<0.001
C_max, μg/L	Intercept	0.34	0.272	0.408	<0.001
C_max, μg/L	Slope	0.659	0.594	0.725	<0.001
C_trough, μg/L	Intercept	–1.14	–1.41	–0.868	<0.001
C_trough, μg/L	Slope	2.27	2.01	2.530	<0.001

AUC_0–24, area under the plasma concentration–time curve from 0 to 24 hours; CI, 95% confidence interval; C_max, maximum concentration; C_trough, trough concentration at the end of the dosing interval before the next dose; PT, prothrombin time.