Table 1.

Disease Genes Identifed Using Positional Cloning

Year	Disease
1986	Chronic Granulomatous Disease Duchenne’s Muscular Dystrophy Retinoblastoma
1989	Cystic Fibrosis
1990	Wilms’ Tumor Neurofibromatosis Type 1 Testis Determining Factor Choroideremia
1991	Fragile X Syndrome Familial Polyposis Coli Kallmann’s Syndrome Aniridia
1992	Myotonic Dystrophy Lowe’s Syndrome Norris’s Syndrome
1993	Menkes’ Disease X-Linked A gammaglobulinemia Glycerol Kinase Deficiency Adrenoleukodystrophy Neurofibromatosis Type 2 Huntington’s Disease von Hippel-Lindau Disease Spinocerebellar Ataxia I Lissencephaly Wilson’s Disease Tuberous Sclerosis
1994	MacLeod’s Syndrome Polycystic Kidney Disease Dentatorubral Pallidoluysian Atrophy Fragile X “E” Achondroplasia Wiskott Aldrich Syndrome Early Onset Breast/Ovarian Cancer (BRCA 1) Diastrophic Dysplasia Aarskog-Scott Syndrome Congenital Adrenal Hypoplasia Emery-Dreifuss Muscular Dystrophy Machado-Joseph Disease
1995	Spinal Muscular Atrophy Chondrodysplasia Punctate Limb-Girdle Muscular Dystrophy Ocular Albinism Ataxia Telangiectasia Alzheimer’s Disease Hypophosphatemic Rickets Hereditary Multiple Exostoses Bloom Syndrome Early Onset Breast Cancer (BRCA 2)