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(a) Photomicrograph of a biopsy specimen from a sigmoid lesion shows high-grade dysplasia within the tubulovillous adenoma (Haematoxylin & eosin, × 100). (b & c) Photomicrographs of an endoscopic submucosal dissection specimen section show (b) invasive adenocarcinoma, moderately differentiated, with submucosal invasion (Haematoxylin & eosin, × 20); and (c) tumour cells and mucin present at the cauterised base margin of the specimen (Haematoxylin & eosin, × 40).
