Table 2.
Baseline characteristics.
| CP (N = 37) | MCI (N = 18) | CI (N = 28) | HC (N = 34) | |
|---|---|---|---|---|
| Age (years) | 51.9 ± 9.9 | 54.6 ± 8.6 | 53.9 ± 9.9 | 50.7 ± 9.8 |
| Sex (female, n (%)) | 27 (73) | 11 (61%) | 17 (61) | 21 (62) |
| Educational level (1–7) | 4.0 (IQR = 3) | 4.0 (IQR = 2.3) | 4.0 (IQR = 3) | 6 (IQR = 2.3) |
| EDSS (0–10)a | 3.0 (IQR = 2.3) | 3.25 (IQR = 2.3) | 4.5 (IQR = 2.5) | – |
| Average cognitionb (Z-score) | −0.24 ± 0.43 | −1.1 ± 0.36 | −1.8 ± 0.58 | −0.09 ± 0.48 |
| Symptom duration (years) | 17.1 ± 6.0 | 19.8 ± 8.3 | 19.7 ± 7.2 | − |
| Diagnosis duration (years) | 13.4 ± 4.1 | 14.7 ± 6.9 | 16.9 ± 7.0 | − |
| NWMV (l) | 0.65 ± 0.037 | 0.67 ± 0.036 | 0.65 ± 0.034 | 0.69 ± 0.024 |
| NCGMV (l)b | 0.74 ± 0.044 | 0.74 ± 0.037 | 0.71 ± 0.051 | 0.76 ± 0.034 |
| NDGMV (l)b | 0.057 ± 0.0056 | 0.055 ± 0.0052 | 0.051 ± 0.0071 | 0.062 ± 0.0029 |
| Thalamic volume (L)b | 0.018 ± 0.0019 | 0.018 ± 0.0019 | 0.016 ± 0.0031 | 0.020 ± 0.0011 |
| White matter lesion load (mL) | 17,414 ± 15,477 | 19,110 ± 15,221 | 31,214 ± 24535 | − |
CP: cognitively preserved; MCI: mild cognitively impaired; CI: cognitively impaired; HC: healthy controls; EDSS: Expanded Disability Status Scale; NWMV: normalized white matter volume; NCGMV: normalized cortical gray matter volume; NDGMV: normalized deep gray matter volume.
Depicted are mean values ± SD or median with the interquartile range (IQR) where appropriate.
a
Significant difference between the CI versus the CP (p-value = 0.037) and the CI versus the MCI (p-value = 0.04) groups.
b
Significant group differences exist, see described in text.