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. 2019 Nov 25;20:249. doi: 10.1186/s13059-019-1824-y

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Single-cell analysis. Distinct cell variation in aging epigenetic clock changes may exist that would not be apparent in bulk comparison. Black and white squares represent methylated and unmethylated loci, respectively. Each row represents a single cell’s epigenome (represented as haploid for simplicity) with increased variability present in individual 2