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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Proteins. 2018 Dec 21;87(2):136–145. doi: 10.1002/prot.25640

FIGURE 6. Sequence alignment of regions C-terminal to domain 21.

FIGURE 6

The transmembrane (gray box) and cytoplasmic region of THSD7A bears a striking resemblance to the corresponding domains of other proteins, such as L-selectin, known to undergo calcium-dependent shedding of the ectodomain. The residues in bold, which extend into the transmembrane region and include a series of basic amino acids in the cytoplasmic juxtamembrane region, are sites of known or proposed (for THSD7A) calmodulin binding. Modified from Gifford et al 2012.