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. 2019 Nov 7;116(47):23724–23734. doi: 10.1073/pnas.1906643116

Fig. 5.

Fig. 5.

Loss of extracellular matrix and lipid deposition in aged Lamp2 KO mice eyes. Immunofluorescent analyses of collagen IV, laminin, fibronectin, APOA1, and APOB in WT and Lamp2 KO mice eyes at 12 mo of age. Unesterified or esterified cholesterol was fluorescently labeled by filipin. n = 6 mice per group; **P < 0.001, ***P < 0.0001. NS, not significant. Student t test. Values are expressed as mean ± SD. (Scale bars: 10 μm.) UC: unesterified cholesterol. EC: esterified cholesterol.