Fig. 6.

ER-stressed DCs activate iNKT cells in vivo. iNKT cell frequency (A) and phenotype (B–D) in spleens isolated from C57BL/6 mice, 24 h after injection of untreated or thapsigargin treated wild-type or CD1d^−/− CD11c⁺ BMDCs. (E) IFN-γ levels in the serum of recipient mice at 3 h. **P < 0.005 and ***P < 0.001 by an unpaired, 2-tailed t test; ns, not significant. Each dot represents a recipient mouse; animals collated from 3 independent experiments for A–D and 1 independent experiment for E.