Fig. 1.

MRTFB depletion enhances cell migration and invasion in CRC cells. (A) Evenly distributed insertions of the SB transposon in both orientations indicate that Mrtfb is a tumor suppressor. Each arrowhead represents a specific insertion of an SB transposon, with right-pointing arrowheads denoting forward insertion events and left-pointing arrowheads denoting reverse insertion events. (B) Low expression levels of MRTFB are associated with poor patient survival in GI tract cancers. (C) RT-qPCR results demonstrated efficient knockdown of MRTFB expression in HCT116 CRC cells. (D) Knockdown of MRTFB led to increased cell invasion. *P < 0.05. (E) Knockdown of MRTFB led to increased cell migration. *P < 0.05.