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. 2019 Nov 6;116(47):23376–23378. doi: 10.1073/pnas.1916214116

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Fig. 1. — Acetylated (Jekyll) and deacetylated (Hyde) SOD2 and cancer stem cell formation. Acetylated SOD2 loses dismutase activity and acquires peroxidase activity that promotes an H₂O₂-dependent feed-forward mechanism for generated further H₂O₂, activating HIF2α and cancer stem cell formation.