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. 2019 Nov 5;116(47):23790–23796. doi: 10.1073/pnas.1908529116

Fig. 1.

Fig. 1.

Abca7 deficiency suppresses inflammatory cytokine expression in the mouse brain on peripheral LPS administration. mRNA expression levels of inflammatory cytokines were analyzed in the cortex (CX; A–C) and hippocampus (HP; D–F) of control (white), Abca7+/− (gray), and Abca7−/− (black) mice at 3.5 h after administration with i.p. LPS injection (control, n = 15; Abca7+/−, n = 17; Abca7−/−, n = 9) or without i.p. LPS injection (control, n = 16; Abca7+/−, n = 18; Abca7−/−, n = 7). The ∆∆Ct values of Il6 (A and D), Tnf (B and E), and Il1b (C and F) relative to Hprt were measured by qRT-PCR. Relative ratios to control mice without LPS administration are shown as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, Tukey–Kramer post hoc analysis of 2-way ANOVA within LPS(−) or LPS(+) groups.