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. 2018 Dec 19;25(14):1915–1925. doi: 10.1177/1352458518814117

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© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — T1-weighted signal intensity in SELs.

CI: confidence interval; PPMS: primary progressive multiple sclerosis; RMS: relapsing multiple sclerosis; SEL: slowly expanding/evolving lesion.

Last visit is Week 96 for OPERA I and OPERA II, and Week 120 for ORATORIO.

^aVan Elteren test; stratified by treatment group (ocrelizumab, control), baseline T2 lesion volume category based on tertiles (⩽3.013 cm³, <3.013 to ⩽11.122 cm³, >11.122 cm³).

*p < 0.001^a for the comparison of absolute T1 intensity of SELs versus non-SELs at each timepoint in RMS and PPMS.

†p < 0.001^a for the change in normalized T1 intensity from baseline to Week 24, Week 48, and Week 96/120 for SELs versus non-SELs in RMS and PPMS, respectively.