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. 2019 May;189. doi: 10.1016/j.jsbmb.2019.01.008

Fig. 3.

Fig. 3

Peripheral venous steroid profiling for the classification of micro-APAs, macro-APAs and BAH.

The random forest algorithm constructed performance estimates for each steroid (Panel A), the first classification tree of the forest is shown for the prediction of micro-APAs, macro-APAs and BAH (Panel B), and a table with the estimated classification by steroid profiling and the actual classification by AVS (to differentiate BAH from APA) and pathology reports (to differentiate micro-APAs from macro-APAs) (Panel C). One patient had outlier steroid profiling results and was omitted. Numbers indicate steroid concentrations in ng/mL. To convert concentrations in ng/mL to pmol/L, concentrations should be divided by the molecular weight of each steroid. Molecular weights: 11-deoxycorticosterone, 330.46; 17-hydroxyprogesterone, 330.46; 18-hydroxycortisol, 378.46; 18-oxocortisol, 376.45; aldosterone, 360.44; corticosterone, 346.46; cortisol, 362.46. 17-OH-progesterone, 17-hydroxyprogesterone; 18OH-cortisol, 18-hydroxycortisol; APA, aldosterone-producing adenoma; BAH, bilateral adrenal hyperplasia; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulphate.