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. 2019 Sep;147:104392. doi: 10.1016/j.phrs.2019.104392

Fig. 1.

Fig. 1

(A) The JAK-Stat signalling pathway. (B) Cytokine signally through JAK/Stat combination.

Upon binding to a cytokine, the cytokine receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific receptor tyrosine residues and recruited STATs. Activated STATs are released from the receptor, dimerize, translocate to the nucleus and bind to members of the GAS (Gamma Activated Site) family of enhancers. Adapted from Kisseleva el al, Gene. 2002; 285 (1-2):1–24.

JAK: Janus kinase; TYK: Tyrosine kinase; STAT: Signal Transducer and Activator of Transcription; IFN: Interferon; IL: Interleukin; EPO: Erythropoietin; GM-CSF: Granulocyte/macrophage colony stimulating factor; TP0: Thrombopoietin. Adapted from Hodge et al. Clin Exp Rheumatol. 2016; 34 (2):318-328.