Fig. 6.

Lens development in Aey69 mutants. The lens-specific marker CRYAA (a) and CRYGD (b) were used to characterize the early lens from the stages of E11.5-E14.5. At E11.5, no major change was observed in the distribution of crystallins between the wild type and mutant lens (marked by their respective arrows). However, through the stages of E12.5 – E14.5 the arrows highlight clearly the decreased CRYAA and CRYGD expression and a diminishing lens region in the mutant. The bars indicate 100 μm; n = 3 for each embryonic stage; L, lens; R, retina; ON, optic nerve.