Table 5.
Evidence of tissue exposure to acetamide in both mice and rats.a.
| Dose (mg/kg/day) | Acetamide Concentration in Plasma in ppm (s.d) |
||||
|---|---|---|---|---|---|
| Mice |
Rats |
||||
| Male | Female | Male | Female | ||
| Acute (2 days) | 0 | 0.4 (0.1) | 0.4 (0.1) | 1.5 (0.3) | 1.5 (0.1) |
| 250 | 35.72 (14.8) | 11.02 (9.7) | 187.02 (56.5) | 127.52 (36.1) | |
| 1000 | 171.32 (106.0) | 68.22 (50.4) | 405.52 (71.2) | 263.42 (66.8) | |
| 2000 | 183.52 (81.7) | 114.82 (58.0) | 827.62 (261.0) | 572.72 (259.0) | |
| Subchronic (28 days) | 0 | NA | NA | 0.6 (0.1) | 0.6 (0.1) |
| 1000 | NA | NA | 517.32 (30.0) | 348.32 (95.2) | |
| 1500 | NA | NA | 593.52 (184.1) | 456.02 (197.1) | |
2Denotes significant difference (p ≤ 0.05) compared to species, sex, and time matched negative control.
a
Data presented is mean of six animals per treatment group with standard deviation in parentheses.