Table II.

Key nodes in the protein-protein interaction network with a degree ≥45.

No.	Name	Degree	Gene title	Function
1	AURKA	50	Aurora kinase A	The protein encoded by AURKA is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation.
2	CCNB1	50	Cyclin B1	The protein encoded by CCNB1 is a regulatory protein involved in mitosis, which is necessary for regulation of the G2/M transition phase of the cell cycle.
3	CDK1	50	Cyclin dependent kinase 1	The protein encoded by CDK1 is a member of the Ser/Thr protein kinase family, which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle.
4	CCNA2	48	Cyclin A2	The protein encoded by CCNA2 binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M.
5	CCNB2	47	Cyclin B2	Cyclin B2 is a member of the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. Cyclin B2 is primarily associated with the Golgi region.
6	KIF2C	46	Kinesin family member 2C	KIF2C encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize micro tubules at the plus end, thereby promoting mitotic chromosome segregation.
7	UBE2C	46	Ubiquitin conjugating enzyme E2 C	UBE2C encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression.
8	RRM2	45	Ribonucleotide reductase regulatory subunit M2	RRM2 encodes one of two non-identical subunits for ribonucleotide reductase. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini.
9	CDC6	45	Cell division cycle 6	The protein encoded by CDC6 is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication.
10	KIF11	45	Kinesin family member 11	The function of KIF11 product includes chromosome positioning, centro some separation and establishing a bipolar spindle during cell mitosis.
11	CDC20	45	Cell division cycle 20	CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for nuclear movement prior to anaphase and chromosome separation.