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. Author manuscript; available in PMC: 2019 Nov 25.
Published in final edited form as: Cell Rep. 2018 Nov 20;25(8):2177–2191.e7. doi: 10.1016/j.celrep.2018.10.082

Figure 2. PAI-1 promotes macrophage migration by interacting with LRP1.

Figure 2.

A-B. PAI-1 expression in HT-1080-Luc-shPAI1 (A), and A549-Luc-shPAI1 (B) cell lines after 3 days of doxycycline treatment. C-D. Migration of human monocytes towards conditioned medium generated from HT-1080-Luc-shPAI1 (C) and A549-Luc-shPAI1 (D) was determined using the Boyden migration assay; E-F. Migration of human monocytes in presence of rPAI-1, rPAI-1 R76E I91L, rPAI-1 T333R A335R (E) and in presence or absence of RAP (F). Data represent the mean number (± SD) of migrated cells in 9 random fields per filter in technical triplicate samples. Two-sided Student t test was applied for comparisons between the groups. The data from a biological duplicate experiment for E and F is presented in Figure S1.