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. Author manuscript; available in PMC: 2019 Nov 25.
Published in final edited form as: Soft Matter. 2019 Feb 6;15(6):1269–1277. doi: 10.1039/c8sm02059k

Fig. 4.

Fig. 4

Partial phase diagram of GMO/DOTAP/DOPE-PEG in excess water constructed from SAXS data. Multilamellar vesicles (MLV) were observed at low GMO concentration (≤ca. 40 : 60 GMO/DOTAP), and bicontinuous cubic phases were observed at high GMO content (≥ca. 85:15 GMO/DOTAP). Symbols identify structures observed with SAXS: lamellar (green triangle), primitive bicontinuous cubic (red square), diamond bicontinuous cubic (blue diamond), gyroid bicontinuous cubic (purple circle). In some instances, a reentrant lamellar phase is observed at high GMO content. Cryo-EM micrographs are consistent with SAXS data. With 5 mol% DOPE-PEG, diamond bicontinuous cubic phases are observed (e.g., 76 : 19 : 5) and the primitive lattices are preferred for 1 mol% (59 : 40 : 1) and 3 mol% (91 : 6 : 3). Fast Fourier transforms of the enlarged areas (inset) confirm the space group symmetries of the cubic phases (orange 3D models). Scale bars are 200 nm.