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. 2019 Nov 5;18(6):6545–6553. doi: 10.3892/ol.2019.11052

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Copyright: © Varallo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Immunohistochemical characteristics of mammary cancer phenotypes in bitches. (A) Photomicrograph of phenotypic profiles classified by immunohistochemical markers of ER, PR and HER-2 in canine mammary tumors. 3,3′-diaminobenzidine chromogen. Scale bar, 20 µm. ER positive and/or PR positive and HER-2 negative signals are associated with the phenotype Luminal A. ER positive and/or PR positive and HER-2 positive signals are associated with the phenotype Luminal B. The phenotype HER-2 upregulated was characterized by ER negative, PR negative and HER-2 positive signals. ER negative, PR negative, and HER-2 negative signals are associated with the triple negative phenotype. (B) Photomicrograph of (B-a) negative human breast cancer control and (B-b) negative to low protein expression of ER, PR, HER-2 and E-cadherin in canine mammary cancer. (B-c) Human samples positive for ER, PR, HER-2 and E-cadherin. Magnification, ×40. Laboratory of Molecular Investigation of Cancer (LIMC), 2019. ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor.