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. 2019 Nov 1;18(6):6759–6765. doi: 10.3892/ol.2019.11030

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Copyright: © Shen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Downregulation of YES1 inhibits cell proliferation in NSCLC. (A) Expression of YES1 was measured in NSCLC tissues and adjacent normal tissues. (B) The expression of YES1 was observed in H1299, A549 and BEAS-2B cell lines. (C) High YES1 expression was related to shorter overall survival in NSCLC patients. (D and E) Combination of unfavorable pattern (low miR-133a expression and high YES1 expression) was evaluated in NSCLC patients using Kaplan-Meier analysis and Cox analysis. (F) Expression of YES1 was observed in A549 and H1299 cells with YES1 siRNA or si-NC. (G and H) The cell proliferation was measured in A549 and H1299 cells with YES1 siRNA or si-NC. *P<0.05, **P<0.01. miR-133a, microRNA-133a; NSCLC, non-small cell lung cancer.