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. Author manuscript; available in PMC: 2019 Nov 25.
Published in final edited form as: J Pediatr Hematol Oncol. 2018 Apr;40(3):208–215. doi: 10.1097/MPH.0000000000001112

Figure 1. Doxorubicin with or without exercise causes weight loss in nude mice.

Figure 1

A) Schematic of study design. Parallel experiments were performed using either A673 tumor-bearing nude mice (TB-NM) or non-tumor bearing C57Bl6/J mice (NTB-IC). For TB-NM, tumor cells were injected subcutaneously and tumors were allowed to establish. After this point, study design was identical in both models. Echocardiograms were performed pre-treatment and after the final doxorubicin dose. Animal weight was monitored over time. Treatment groups included control (saline injection, no exercise); exercise alone (treadmill exercise 5 days per week, 45 minutes per day, 12 meters/min); Doxo alone (4 total doses of 2.5mg/kg doxorubicin given on days 9, 11, 16, 18); combination Doxo and exercise. B) Animal weight was tracked over time. Graphs show the mean difference in starting and final animal weight per treatment group +/− standard deviation, separated by TB-NM or NTB-IC mice, respectively. N = 6-12 per group.