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. 2019 Nov 15;9:1163. doi: 10.3389/fonc.2019.01163

Figure 5.

Figure 5

miR-184 inhibits proliferation, migration, and invasion of retinoblastoma (RB) cells via targeting SLC7A5. (A) Western blot analysis of SLC7A5 expression in Y79 cells and WERI cells transfected with SLC7A5 siRNA. (B) EdU analysis of the cell proliferation ability in Y79 cells transfected with the SLC7A5 siRNA. (C) Statistical analysis of the EdU-positive cell ratio in Y79 cells and WERI cells transfected with the SLC7A5 siRNA. (D) Transwell assay of the migration and invasion ability inY79 cells transfected with the SLC7A5 siRNA. Scale bar: 100 μm. (E) Statistical analysis of the cell numbers through the chamber in WERI cells transfected with the SLC7A5 siRNA. (F) EdU analysis of the cell proliferation ability in Y79 cells transfected with miR-184 mimic alone or together with SLC7A5 expression vector (pcDNA3.1-SLC7A5). (G) Transwell assay of the migration and invasion ability in Y79 cells transfected with miR-184 mimic alone or together with SLC7A5 expression vector (pcDNA3.1-SLC7A5). Data were presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.0001 vs. negative control group.